GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11976180 | 1 | rs13226728 | chr7:143746578 | OR2A7 | chr7:143955790-143974852:- | 0.2 | 4.67 | 3.41E-6 | Obesity-related traits |
| BRCA | cis | rs2243480 | 1 | rs13235972 | chr7:65883605 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 6.53 | 1.02E-10 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13235972 | chr7:65883605 | CRCP | chr7:65579805-65619551:+ | -0.21 | -3.51 | 0.00046 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13235972 | chr7:65883605 | LOC493754 | chr7:65993446-66057363:- | 0.22 | 3.7 | 0.000228 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13237037 | chr7:65997882 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 6.67 | 4.12E-11 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13237037 | chr7:65997882 | LOC493754 | chr7:65993446-66057363:- | 0.24 | 4.06 | 5.38E-5 | Diabetic kidney disease |
| BRCA | cis | rs10486607 | 1 | rs13238274 | chr7:29180335 | CPVL | chr7:29035249-29234892:- | -0.16 | -4.79 | 1.9E-6 | Diabetes related insulin traits |
| BRCA | cis | rs13240464 | 1 | rs13239254 | chr7:110917686 | IMMP2L | chr7:110303110-111202538:- | 0.16 | 4.29 | 1.95E-5 | Schizophrenia |
| BRCA | cis | rs801193 | 1 | rs13239306 | chr7:66136017 | TYW1 | chr7:66461817-66704496:+ | -0.16 | -4.29 | 1.98E-5 | Aortic root size |
| BRCA | cis | rs13240464 | 1 | rs13240464 | chr7:110898915 | IMMP2L | chr7:110303110-111202538:- | 0.15 | 4.04 | 5.79E-5 | Schizophrenia |
| BRCA | cis | rs11976180 | 1 | rs13243677 | chr7:143746572 | ARHGEF35 | chr7:143883677-143892736:- | -0.4 | -9.98 | 1.72E-22 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs13243677 | chr7:143746572 | OR2A7 | chr7:143955790-143974852:- | 0.2 | 4.8 | 1.8E-6 | Obesity-related traits |
| BRCA | cis | rs10486607 | 1 | rs13245225 | chr7:29181626 | CPVL | chr7:29035249-29234892:- | -0.17 | -5.04 | 5.51E-7 | Diabetes related insulin traits |
| BRCA | cis | rs2243480 | 1 | rs13247184 | chr7:65358928 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 7.02 | 3.88E-12 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs13247184 | chr7:65358928 | LOC493754 | chr7:65993446-66057363:- | 0.2 | 3.38 | 0.00075 | Diabetic kidney disease |